Medical Flow Physics Laboratory (MFPL)

USC Michelson Center for Convergent Bioscience

Department of Aerospace & Mechanical Engineering

OUR PATENT AND INVENTIONS

  1. Inventions

  2. iPhone Ejection Fraction App

  3. Our group (in Collaboration with Dr. Rinderknecht, Dr. Tavallai, and Dr. Gharib) has developed and validated an iPhone application (see the paper here) that uses a regular (unmodified) iPhone to compute left ventricle ejection fraction (LVEF) form the carotid pulse.
  1. Smartphone-Based Cardiovascular Monitoring System

  2. Our group (in Collaboration with Dr. Rinderknecht and Dr. Gharib) has developed an inexpensive, noninvasive and easy-to-use cardiovascular monitoring system that can measure arterial pressure waveform and phonocardiogram simultaneously with a simple measurement. This system provides clinically relevant information for various cardiovascular diseases.
  1. Issued Patents

  2. 5- Pahlevan NM, Tavallali P, Rinderknecht DG, and M Gharib. “Intrinsic frequency analysis for left ventricle ejection fraction or stroke volume determination” (US9480406B2). (licensed to industry)
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  4. 4- Rinderknecht DG, Pahlevan NM, Tavallali P, and M Gharib. “Portable electronic hemodynamic sensor systems” (US10918291B2). (licensed to industry)
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  6. 3- Pahlevan NM and M. Gharib. “Noninvasive Systems for Blood Pressure Measurement in Arteries” (US9622666B2). (licensed to industry)
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  8. 2- Pahlevan NM, Tavallali P, Hou TY, and M Gharib.“Intrinsic Frequency Hemodynamic Waveform Analysis” (US9026193B2). (licensed to industry)
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  10. 1- Gharib M and Pahlevan NM. “Correction and Optimization of Wave Reflection in Blood Vessels" (US9125655B2).
  1. US Patent Applications

  2. 11- Herrington CS, Menteer JD, Badran S, Wei H, and NM Pahlevan. “Artificial right atrium design for failing fontans” (US20210154385A1)
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  4. 10- Pahlevan NM and M Gharib. “Method and apparatus for left ventricular end diastolic pressure measurement” (US20200359912A1) (licensed to industry)
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  6. 9- Alavi R, Dai W, Kloner RA, and Pahlevan NM. “Noninvasive infarct size determination” (63/111,798)
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  8. 8- Rinderknecht DG, Gharib M, Pahlevan NM, and P Tavallali. “Heart sound and pulse waveform acquisition and analysis” (US20170020400A1) (licensed to industry)
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  10. 7- Liu J and Pahlevan NM. “Non-invasive determination of left ventricle pressure-volume loops for evaluating cardiac functions and ventricular-arterial coupling”
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  12. 6- Petrasek D, Pahlevan NM, and M Gharib.“Intrinsic frequency based determination of insulin resistance” (US20150201883A1 and WO2015112630A1) (licensed to industry)
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  14. 5- Pahlevan NM, Gharib M, and M Csete. “Vessel compression with hemodynamic wave reflection to control vascular wave dynamics and enhance blood flow” (US20210205598A1)
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  16. 4- Alavi R, Dai W, Kloner RA, and Pahlevan NM. “Noninvasive cardiovascular event detection” (63/111,798)
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  18. 3- Pahlevan NM and M Gharib. “Noninvasive Systems for Aortic Aneurysm Evaluation” (US20140046202A1) (licensed to industry)
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  20. 2- Rinderknecht DG, Pahlevan NM, Tavallali P, and M Gharib.“Portable electronic hemodynamic sensor systems” (US20160135697A1) (licensed to industry)
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  22. 1- Pahlevan NM, McGrath WR, and M Gharib. “Cardiac Microwave Signal Determination of Cardiovascular Diseases” (US20140163362A1)