Medical Flow Physics Laboratory (MFPL)

USC Michelson Center for Convergent Bioscience

Department of Aerospace & Mechanical Engineering

OUR PATENT AND INVENTIONS

  1. Inventions

  3. iPhone Ejection Fraction App

  5. Our group (in Collaboration with Dr. Rinderknecht, Dr. Tavallai, and Dr. Gharib) has developed and validated an iPhone application (see the paper here) that uses a regular (unmodified) iPhone to compute left ventricle ejection fraction (LVEF) form the carotid pulse.

  1. Smartphone-Based Cardiovascular Monitoring System

  3. Our group (in Collaboration with Dr. Rinderknecht and Dr. Gharib) has developed an inexpensive, noninvasive and easy-to-use cardiovascular monitoring system that can measure arterial pressure waveform and phonocardiogram simultaneously with a simple measurement. This system provides clinically relevant information for various cardiovascular diseases.

  1. Issued Patents

  2. 9- Pahlevan NM, Gharib M, and M Csete. (2024) “Vessel compression with hemodynamic wave reflection to control vascular wave dynamics and enhance blood flow” (US12005246B2)
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  4. 8- Herrington CS, Menteer JD, Badran S, Wei H, and NM Pahlevan. (2024) “Artificial right atrium design for failing fontans” (US-12121712-B2)
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  6. 7- Gharib M and Pahlevan NM. (2023) “Method and apparatus for left ventricular end diastolic pressure measurement” (US11730376B2). (licensed to industry)
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  8. 6- Rinderknecht DG, Pahlevan NM, Tavallali P, and M Gharib. (2021) “Portable electronic hemodynamic sensor systems” (US10918291B2). (licensed to industry)
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  10. 5- Pahlevan NM and M. Gharib. (2017) “Noninvasive Systems for Blood Pressure Measurement in Arteries” (US9622666B2). (licensed to industry)
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  12. 4- Pahlevan NM, Tavallali P, Rinderknecht DG, and M Gharib. (2016) “Intrinsic frequency analysis for left ventricle ejection fraction or stroke volume determination” (US9480406B2). (licensed to industry)
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  14. 3- Pahlevan NM, Tavallali P, Hou TY, and M Gharib. (2016) “Intrinsic Frequency Hemodynamic Waveform Analysis” (US9026193B2). (licensed to industry)
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  16. 2- Pahlevan NM and M Gharib. (2017) “Noninvasive Systems for Aortic Aneurysm Evaluation” (CN104619244B)
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  18. 1- Gharib M and Pahlevan NM. (2015) “Correction and Optimization of Wave Reflection in Blood Vessels" (US9125655B2).

  1. US Patent Applications

  2. 9- Alavi R, Amlani F, Gorji H, Niroumandijahromi S, Heng Wei H, and Pahlevan NM. (2024) “Sequentially-Reduced Artificial Intelligence Based Systems And Methods For Cardiovascular Transfer Functions” (US-20230138773-A1)
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  4. 8- Pahlevan NM and Aghilinejad A. (2024) “Longitudinal impedance pump” (US20240167467A1)
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  6. 7- Pahlevan NM, Alavi R, Wang Q, and Gorji H. (2023) “Sequentially-reduced Artificial intelligence methodology for instantaneous determination of waveform intrinsic frequencies” (US-20230148969-A1)
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  8. 6- Pahlevan NM, Alavi R, Dai W, Kloner RA. (2021) “Noninvasive infarct size determination” (US20230389850A1)
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  10. 5- Pahlevan NM, Alavi R, and Matthews RV. (2021) “Noninvasive heart failure detection” (US20230420132A1)
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  12. 4- Pahlevan NM, Alavi R, Dai W, and Kloner RA. (2021) “Noninvasive cardiovascular event detection” (US20230404488A1)
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  14. 3- Rinderknecht DG, Gharib M, Pahlevan NM, and P Tavallali. (2019) “Heart sound and pulse waveform acquisition and analysis” (US20170020400A1) (licensed to industry)
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  16. 2- Petrasek D, Pahlevan NM, and M Gharib. (2015) “Intrinsic frequency based determination of insulin resistance” (US20150201883A1 and WO2015112630A1) (licensed to industry)
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  18. 1- Pahlevan NM, McGrath WR, and M Gharib. (2014) “Cardiac Microwave Signal Determination of Cardiovascular Diseases” (US20140163362A1)